![]() Herein, we discover that mis-spliced RNA itself is a molecular trigger for tumor killing through viral mimicry. However, the mechanisms by which STTs selectively kill cancers remain largely unknown. ![]() Electronic address: oncogenic insults deregulate RNA splicing, often leading to hypersensitivity of tumors to spliceosome-targeted therapies (STTs). 17 Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA Therapeutic Innovation Center, Baylor College of Medicine, Houston, TX 77030, USA.Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA. 16 Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA Dan L.15 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA Therapeutic Innovation Center, Baylor College of Medicine, Houston, TX 77030, USA Dan L.14 H3Biomedicine, Cambridge, MA 02139, USA.13 Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.12 Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA Therapeutic Innovation Center, Baylor College of Medicine, Houston, TX 77030, USA. ![]() 11 Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA Dan L.10 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA Dan L.9 Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA Dan L.8 Therapeutic Innovation Center, Baylor College of Medicine, Houston, TX 77030, USA.7 Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA.6 Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA.5 Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. ![]()
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